Fast scanning for large samples

The Dimension FastScan Bio Atomic Force Microscope (AFM) enables high-resolution research of biological dynamics, with temporal resolution of up to 3 frames-per-second for live sample observations. What’s more, it does this while making the AFM easier to use than ever before. Built upon the world’s most advanced large-sample AFM platform, the FastScan Bio AFM adds specialized life science features to this platform for high-resolution, live-sample observation of interacting molecules, membrane proteins, DNA protein binding, inter-cellular signaling and many other dynamic biological studies.

Real-time
panning, zooming and scanning
Allow researchers to observe and study how biomolecular mechanisms function.

Simplified
sample engaging and controls
Deliver easy and immediate nanoscale bioimaging.

Smart Engage
algorithms
Provide flexibility for commercially available or custom-made probes.

FEATURES

High-Resolution Biological Dynamics
In-situ high-resolution dynamic studies with nanoscale resolution are a reality for a rapidly evolving branch of biological research. Dimension FastScan Bio breaks longstanding barriers to provide these capabilities for routine experimentation. These breakthroughs allow many more researchers to observe and study biomolecular structures and mechanisms. FastScan Bio’s high-resolution and high-speed scanning provide the best available bio tool for the observation of molecules, proteins, DNA, RNA, living cell membranes and tissues, and many other dynamics studies.

Technology Designed for Live Samples
FastScan Bio's innovative AFM technology enables high-speed scanning and a seamless user interface to render immediate panning, zooming and continuous tracking of samples in fluid. Bruker’s new innovative probe design with unique cantilever shape and coating enables an uprecedented combination of imaging speed and softness. The resulting system delivers the scanning speed required for high-resolution spatiotemporal studies with the greatest simplicity ever seen in a commercial AFM system.

• Simplified sample engaging and controls for immediate imaging
• Real-time panning, zooming and scanning
• Feature tracking and Movie creation tool
• Micro-volume fluid cell with controlled fluid exchange

For more information please visit:
https://www.bruker.com/en/products-and-solutions/microscopes/bioafm/dimension-fastscan-bio.html

Highest resolution and most complete biomechanics

Bruker’s BioScope Resolve BioAFM features the highest resolution atomic force microscopy imaging and most complete cell mechanics capabilities available for use with an inverted optical microscope. BioScope Resolve incorporates Bruker’s exclusive PeakForce Tapping technology to enable researchers to achieve the highest resolution biological imaging and piconewton-level force measurements and spectroscopy at every pixel. The system’s real-time synchronization of optical and atomic force microscopy data opens the door to previously inaccessible data, including physical structure, biochemical interactions, and mechanical properties, to provide unique insights into life sciences research.

Quantitative
mapping
Reveals live-cell mechanical, chemical, and biological interactions.

Highest
resolution
Views molecular and cellular samples at the nanoscale.

Seamless
integration
Between AFM and inverted optical microscope for unsurpassed correlation of data.

FEATURES

Accurate, Repeatable, and Complete Cell Mechanics Data
Ultimate force control — PeakForce QNM®, has become the preferred mode for nanomechanical mapping. With new algorithms, it delivers highest resolution property maps at pN forces on live cells. Together with “No Touch” tip calibration, PeakForce QNM delivers the fastest quantitative mechanical characterization of live cells, providing a complete force curve for every pixel at actuation rates from 125 Hz to 2 kHz.

Widest range of ramp rates — At the core of quantitative nanomechanical maps are force-distance curves. Beyond characterizing elastic response, ramp rate dependent data provides insight into viscoelasticity or into molecular interaction times at the single molecule level. With our new FASTForce Volume covering rates from sub-Hz to 300 Hz, and PeakForce Tapping extending to 2 kHz, we provide the widest range of ramp rates for single points and imaging while maintaining pN force control.

Covering the whole spectrum — Our new RampScript™ allows the user to build, control and record complex nanomechanical measurements for use in protein pulling, ligand-receptor interaction, cell relaxation and viscoelastic probing. Its low force trigger capability, and latency-free implementation build on the system’s core performance to provide the most accurate script execution and force control. Ramping scripts are created in an intuitive drag and drop process and provide ultimate flexibility including per segment optical synchronization.

BioScope Resolve microvilli topography modulus
PeakForce QNM topography image (left) and corresponding modulus image (right) of living MDCK cells. Cell structures corresponding to actin fibers show higher modulus (lighter) while cell surface features, believed to be microvilli, appear softer (darker) than the cell membrane itself. (1 kHz PeakForce QNM, 32 μm image).

Cell Dynamics Without Compromise
Fast Tapping on living cells - Bioscope Resolve is the only BioAFM that enables fast scanning while simultaneously providing the large piezo scanner range necessary for capturing the dynamic behavior of living cells in real time (XYZ = 100µm x 100µm x 15µm). The Fast Tapping capabilities of Resolve are truly a step forward in conducting high-resolution AFM studies at timescales relevant to cellular processes. Together with the integration of advanced optical microscopy and environmental control, live cell studies have never been easier.

Seamlessly Combined Fluorescence and Biomechanics
Expanded measurement possibilities — The MIROView GUI ensures expert data generation via fully synchronized AFM images, force maps, and single-force curves with optical images and data.

Great optical integration — BioScope Resolve AFM works seamlessly with an optical microscope, thanks to communication protocols developed with researchers’ applications in mind. Pixel by pixel, line by line, and image by image, optical synchronization delivers flexibility never seen before on an AFM.

The perfect environment — With a new acoustic hood, work station, and a complete suite of life science research accessories, such as a sample heater, perfusion cell, and a top-down camera, the BioScope Resolve provides all your bioAFM research needs.

For more information, please visit:
https://www.bruker.com/en/products-and-solutions/microscopes/bioafm/bioscope-resolve.html

First-and-only no-compromise high-speed AFM

The Dimension FastScan® atomic force microscope (AFM) system is specifically designed to scan fast without loss of resolution, loss of force control, added complexity, or additional operating costs. With FastScan you achieve immediate AFM images with the expected high resolution of a high-performance AFM. Whether you scan at >125Hz when surveying a sample to find the region of interest, or at time rates of 1-second per image frame in air or fluid, FastScan redefines the AFM experience.

No-compromise
high-speed performance
Delivers highest resolution any time, every time, independent of sample size.

Real-time
nanoscale dynamics
Provide ultimate tip-scanning speed and stability for direct visualization of dynamic behavior in air or fluid.

Automated
setup, data acquisition, and analysis
Makes system operation surprisingly simple while enhancing prductivity, allowing you to focus on your research.

FEATURES

Benchmark for High Speed and High Resolution
Dimension FastScan is the first-and-only high-speed tip-scanning system that achieves frames per second scan rates without compromising resolution or system performance – independent of sample size. No other high-speed AFM has the large sample access of the FastScan. Coupled with PeakForce Tapping®, the system achieves instantaneous force measurement with a linear control loop, allowing point defect dimensional and mechanical resolution, and not just on hard, flat crystals.

Exceptional Productivity
Every facet of the Dimension FastScan — from wide-open tip and sample access to preconfigured software settings — has been specifically engineered for trouble-free, surprisingly simple operation. Fast sample navigation, fast engaging, fast scanning, low-noise, less than 200 pm per minute of drift rate over hours, an expanded intuitive user interface, and the world-renowned Dimension platform combine to deliver an entirely new experience in AFM, while ensuring high-quality data with faster time to results and publication. FastScan users can achieve immediate high-quality results without the usual hours of expert tweaking.

More Applications and New Insights Faster
Sample surveying is a common way to explore unknown samples to understand heterogeneity, unique feature characteristics, and mechanical properties. Here are the results of a FastScan sample survey, which produced a set of high-quality images ranging from high-resolution topography images of a 20 μm area to subsections 10 times smaller than the original scan. The results from one 8 minute scan are 16 megapixels of data in multiple channels, where high-resolution data is observed with clarity.

AFM MODES
Expand Your Applications with AFM Modes
With an unrivalled suite of imaging modes available, Bruker has an AFM technique for every investigation.

Built on the backbone of core imaging modes—Contact Mode and Tapping Mode—Bruker offers AFM modes that allow users to probe their samples’ electrical, magnetic, or materials properties. Bruker’s innovative new PeakForce Tapping technology represents a new core imaging paradigm that has been incorporated into several modes, providing topographic, electrical, and mechanical properties data in parallel.

For more information please visit:
https://www.bruker.com/en/products-and-solutions/microscopes/materials-afm/dimension-fastscan.html

Specialized solutions for applications ranging from BioAFM and Polymer Research to Surface Science and NanoOptics

The NanoWizard® is the most flexible high-end AFM on the market. It sets the benchmark in resolution, speed and stability in particular for fluid applications. All NanoWizard® systems provide true integration of AFM with optical microscopy by means of our patented DirectOverlay™ feature for precise and easy work, and comes with a large variety of options and accessories. In addition, the NanoWizard® family comes with the QI™ Mode, an easy and intuitive imaging mode for quantitative imaging.

NanoRacer® High-Speed AFM
True high-speed imaging at 50 frames per second and exceptional usability for following molecular dynamics in real-time

NanoWizard® ULTRA Speed 2 AFM
High-speed imaging and super-resolution AFM on inverted microscopes, paired with unparalleled flexibility.

NanoWizard 4 XP BioScience AFM
Extreme performance and ease of use for applications in Life Science and Soft Matter research ranging from single molecules to living cells and tissues.

NanoWizard 4 XP NanoScience AFM
Extreme performance and highest flexibility for applications in materials and polymer science ranging from nanomechanics and electrochemistry to electrical and magnetic measurements.

NanoWizard® Sense+ AFM
The perfect start to AFM, for applications in material and life sciences.

NanoWizard® NanoOptics AFM
Comprehensive solution for advanced experiments which combine AFM and optical spectroscopy such as TERS, Aperture SNOM and sSNOM, confocal microscopy and nano manipulation in optical fields.

BioMAT™ Workstation
For opaque samples, combining upright optical microscopy with AFM for surface science and life science.

OT-AFM Combi-System
NanoTracker™ & NanoWizard® - Powerful combination of Optical Tweezers & AFM in one system for force measurements in 2D and 3D from 500fN to 10nN.

For more information, please visit:
https://www.jpk.com/products/atomic-force-microscopy

A new benchmark: True atomic resolution and high-speed imaging with 10 frames/sec

The JPK NanoWizard® ULTRA Speed 2 delivers exceptional performance and unmatched user-friendliness. It reaches speed levels previously unattainable with traditional AFMs and combines true atomic resolution and fastest scanning with rates of 10 frames/sec. Real-time, in-situ experiments can be performed in combination with advanced optics. A broad range of modes and accessories makes the system highly flexible and upgradable.

The NanoWizard ULTRA Speed 2 provides a range of new features:
• NestedScanner Technology for high-speed imaging of surface structures up to 8µm with outstanding resolution and stability
• PeakForce Tapping® for easy imaging
• New tiling functionality for automated mapping of large sample areas
• V7 Software with revolutionary new workflow-based user interface
• DirectOverlay™ 2 software for perfect integration and data correlation with advanced fluorescence microscopy platforms
• Vortis™ 2 controller for high-speed signal processing and lowest noise levels

High-speed imaging of surface structures up to 8µm with outstanding resolution and stability
The system comes with the lowest noise and highest stability available on the market to provide true atomic resolution. Direct force control at ultra-low forces prevents damage to your samples and probes. With the state-of-the-art position sensor technology, the system delivers highest accuracy and maximum precision.

Until now, performing dynamic experiments on living cells, highly corrugated samples or steep surface structures with highest spatial and temporal resolution was challenging. With our new NestedScanner technology, cells, bacteria or structured surfaces with samples heights up to 8µm can now be examined at the highest scan speeds.

• Observe sample dynamics in real-time with highest resolution
• Access to corrugated and higher surfaces with the NestedScanner technology
• Combine AFM and optical fluorescence microscopy for multiparametric in-situ experiments
• Enhance productivity, probe more sample positions faster

Key features
• High-speed imaging with 10 frames/sec with excellent resolution
• Now with Bruker’s exclusive PeakForce Tapping as standard
• Revolutionary new workflow-based user interface for ergonomics and ease of operation
• New tiling functionality for automated mapping of large sample areas together with the HybridStage
• Unique integration with optical microscopy by tip-scanning design and the newly enhanced DirectOverlay 2 mode for most precise correlative microscopy
• New Vortis 2 controller with high-speed low-noise DACs and cutting-edge position sensor readout technology
• Highest flexibility and upgradeability with a broad range of modes and accessories

For more information, please visit:
https://www.jpk.com/products/atomic-force-microscopy/nanowizard-ultra-speed-2

"The Thermo ScientificTM Phenom Pharos is a desktop SEM with an FEG source that makes crisp, high-brightness images and the benefits of an FEG source accessible to everyone. It is also easy to operate, from the initial installation to the actual usage, thanks to its intuitive and compact design.

The advanced hardware design and detectors enable a fast time to image and easy, foolproof handling.

Phenom Pharos Desktop SEM. Resolution. Re-imagined."

Translational, Cryogen-free, preclinical MRI – MRS 3000TM Series

The revolutionary MRS 3000 preclinical MRI systems are leading edge, cost-effective translational preclinical MRI instruments, providing superior soft tissue contrast and molecular imaging capability. The cryogen-free superconducting, dry magnets offer variable field strengths from 0.1T to 3T and have almost no fringe field, allowing safe use in any facility or existing laboratory and by any operator, with low running costs and no special site requirements advancing your small animal research. The MRS MRI systems require NO LIQUID HELIUM, Dry Magnets.

The MRS 3000 series MRI systems are designed to complement and enable multi-modality imaging. Delivering powerful performance and ease-of-use. The systems are compact with a small footprint design that can be placed in close proximity to other imaging modalities.

Features & Benefits:

• Superior soft tissue contrast and molecular imaging capability for great visualization, quantification and translational studies
• High spatial resolution for great visualization and quantification
• Superior field homogeneity, minimal noise and no temperature drift
• Easy translational research with variable field strengths of 0.1T – 3.0T
• Complete animal handling solution
• Compact with almost no fringe field
• Dry magnet, no liquid Helium required
• Multi-modality imaging; it can be installed in close proximity to other imaging modalities such as SPECT, PET, etc.
• Available in 17cm or 31cm bore sizes enabling studies with a variety of animal models, e.g. mice, rats, guinea pigs, rabbits, small monkey families and more.

One source with two high-flux wavelengths is the foundation of the revolutionary XtaLAB Synergy-DW single crystal X-ray diffractometer. It combines the increased flux of a rotating anode X-ray source with the flexibility of two different wavelengths, making it ideal for laboratories exploring a wide range of research interests.

Configuration

The XtaLAB Synergy-DW diffractometer is based on the proven, low-maintenance MicroMax-007 HF microfocus rotating anode. The target is constructed with two different X-ray source materials (Cu and Mo) and is coupled with an auto-switching dual wavelength optic. Copper or molybdenum X-ray radiation is available at the click of a button. The XtaLAB Synergy-DW offers up to 12x higher flux compared to the standard sealed tube X-ray sources and, utilizing only one generator, means overall maintenance is reduced.
Rounding out the XtaLAB Synergy-DW configuration is the fast and efficient four-circle kappa goniometer which is compatible with a wide range of detectors including the HyPix-6000HE and other Hybrid Photon Counting (HPC) X-ray detectors e.g. PILATUS and EIGER detectors.

Features:

• Access to two wavelengths in one compact system
• 12x higher flux than sealed tube X-ray sources
• Low maintenance, high performance system
• Uses CrysAlisPro software with both PX and SMX modes

Benefits

• Multi-functional diffractometer to cover you wherever your research takes you
• High flux performance means you all your crystallography needs can be carried out ‘in-house’
• Very little downtime and easy maintenance
• No need to purchase extra software for different applications

In situ X-ray crystallography system with imager

The PX Scanner is a fully integrated system for in situ screening and data collection of crystals in SBS crystallization plates and microfluidic chips. This turnkey system combines sample visualization and in situ X-ray screening to deliver a compact tool to evaluate sample quality without the need to remove crystals from their protected growth environment. The system includes a microfocus sealed tube Cu X-ray generator, crystal imaging system, automated tray stage with 6 degrees of tilt, CCD detector and intuitive CrystalEyes software. With the PX Scanner, one can quickly identify whether a crystal contains salt or protein and evaluate diffraction quality for samples without removal from the crystallization plate.

CrystalEyes software

The PX Scanner features the CrystalEyes software that allows users to queue screening of multiple crystals from multiple drops for immediate screening. The software includes automatic data reduction tools and an easy to use GUI for reviewing images and X-ray diffraction results.

Features

• Microfocus sealed tube Cu source
• 135 mm CCD detector
• Touch-screen control for loading and unloading plates
• Barcode reader for plate identification
• Compact footprint

With your success utmost in our minds, we have developed the XtaLAB Synergy-S X-ray diffractometer for single crystal X-ray diffraction. Using a combination of leading edge components and user-inspired software tied together through a highly parallelized architecture, the XtaLAB Synergy-S produces fast, precise data in an intelligent fashion.

The system is based around the PhotonJet-S series of microfocus X-ray sources that incorporate continuously variable divergence slits. These third generation sources have been designed to maximize X-ray photons at the sample by using a combination of new optics, new, longer life, tubes and an improved alignment system. PhotonJets are available in Cu, Mo or Ag wavelengths in either a single or dual source configuration.

The XtaLAB Synergy-S single crystal X-ray diffractometer comes with kappa goniometer that incorporates fast motor speeds and a unique telescopic two-theta arm to provide total flexibility for your diffraction experiment. The system is also equipped with your choice of HPC X-ray detector, including the HyPix-6000HE, PILATUS3 R 200K, PILATUS3 R 300K or EIGER 1M.

Benefits:

• Extremely high performance due to bright source, noise-free X-ray detector and fast goniometer speeds
• Continuously variable divergence slit option lets you resolve reflections from long unit cells.
• Minimal downtime with longer X-ray tube lifetime - supported by online diagnostics and troubleshooting
• Compact design to fit in your laboratory

Features:

• High source flux and increased goniometer speed to allow quicker, more agile experiments
• Unique telescopic two-theta arm to reach both longer and shorter crystal-to-detector distances
• Enhanced kappa goniometer design with symmetrical 2θ positioning
• Improved X-ray optic alignment mechanism for easy maintenance
• User-inspired cabinet design for improved workflow
• New electronically controlled brightness of cabinet and crystal lighting