• (1) AFM / SCANNING MODE / HIGH RESOLUTION
    PeakForce Tapping®

    Bruker’s exclusive PeakForce Tapping® is the most significant scientific breakthrough in atomic force microscope (AFM) technology since the introduction of TappingMode™. It provides unprecedented high-resolution imaging, extends AFM measurements into a range of samples not previously accessed, and uniquely enables simultaneous nanoscale property mapping.

    Highest resolution imaging
    PeakForce Tapping enables the researcher to precisely control probe-to-sample interaction, providing the lowest available imaging forces. This superior force control results in the most consistent, highest resolution AFM imaging for the widest range of sample types, from the softest biological samples to very hard materials.

    Unique, quantitative results, whatever you measure
    PeakForce Tapping’s piconewton (pN) force sensitivity simultaneously and uniquely combines the highest resolution AFM imaging with quantitative, nanoscale electrical, mechanical, biological, and chemical property mapping, enabling researchers of all experience levels to make new discoveries.

    Easy to use, making every user an AFM expert
    PeakForce Tapping’s superior force control provides the user with unmatched AFM ease of use with ScanAsyst® image optimization software, and the low forces preserve the probe shape for longer life and more consistent imaging.

    Featured on the following Bruker AFMs:
    • Dimension FastScan®
    • Dimension FastScan Bio™
    • Dimension Icon®
    • Dimension Icon-Raman™
    • Inspire™
    • BioScope Resolve™
    • MultiMode® 8
    • Dimension Edge™

    For more information, please visit:
    https://www.bruker.com/products/surface-analysis/atomic-force-microscopes/modes/modes/imaging-modes/peakforce-tapping/overview.html

  • (3) AFM / LIFE SCIENCE / FAST SCAN
    Dimension Fastscan Bio

    The Dimension FastScan Bio™ Atomic Force Microscope (AFM) breaks longstanding barriers to provide routine high-resolution research of biological dynamics, with temporal resolution up to 3 frames per second for live sample observations. Furthermore, it does this while making the AFM easier to use than ever before.

    These breakthroughs allow many more researchers to observe and study the mechanisms biomolecular machines utilize to perform their biological functions. FastScan Bio’s high-resolution and high-speed scanning provide the best available bio tool for the observation of molecules, proteins, DNA, RNA, living cell membranes and tissues, and many other dynamics studies.

    Greatest Productivity Seen on Any AFM
    „„• FastScan Bio enables high-speed scanning, in conjunction with a seamless user interface for panning, zooming and continuous tracking of samples in fluid to render faster results.
    „„• A single-scan speed slider facilitates immediate access to scan rate control without the complexity of multiparametric adjustment.
    „„• On-board data and image manipulation tools present final data as high-resolution AFM images or experiment session movies.

    Immediate Path to Data Collection on Live Samples
    • „„Smart Engage algorithms take ambiguity out of the experiment process and provide flexibility for commercially available or custom-made probes.
    „„• User interface controls automate laser and detector alignment with a comprehensive workflow for faster time to data.
    • „„Quick sample engaging and immediate imaging are routine.

    More Options to Optimize Biological AFM Experiments
    „„• Innovative FastScan AFM technology enables high-speed scanning and a seamless user interface to render immediate panning, zooming and continuous tracking of samples in fluid.
    „„• FastScan Bio AFM allows direct visualization of biomolecules with an unprecedented combination of spatial and time resolution.

    For more information, please visit:
    https://www.bruker.com/products/surface-and-dimensional-analysis/atomic-force-microscopes/dimension-fastscan-bio/overview.html

  • (4) AFM / LIFE SCIENCE / FLUORESCENCE
    BioScope Resolve

    The BioScope Resolve™ BioAFM provides the highest resolution imaging, most complete biomechanics capabilities, and fastest scanning of any bioAFM available. Specifically designed for integration onto inverted optical light and confocal microscopes, it enables investigation of a wide range of biological samples, from cells and tissues to molecular and protein structures. The New MIROView™ interface provides unique data sets by combining AFM biomechanics data with real-time confocal and fluorescence microscopy.

    BioScope Resolve's seamless integration of atomic force microscopy and light microscopy reveals more detail and information of biological samples including mechanical properties. The system's unique design makes combined optical and AFM research easy with its open access to the sample, single instrument setup, and correlated data collection and analysis. Researchers can now perfectly connect real-time optical images with AFM imaging.

    The new MIROView graphical interface and ScanAsyst-Cell mode ensure expert data generation, regardless of the user’s AFM experience level. Other features include:
    • Integrates with all major microscope models and optical techniques
    • Single, integrated view and operation controls for AFM or optical microscope
    • Syncronized AFM images, force maps and single force curves with optical images and data
    • Point-and-click setup for automated force and imaging measurements
    • Video creation of experiments showing optical and AFM results
    • BioAFM accessories and PeakForce Tapping probes to meet every application

    For more information, please visit:
    https://www.bruker.com/products/surface-analysis/atomic-force-microscopes/bioscope-resolve/overview.html

  • CORRELATIVE MICROSCOPY / OPTICAL MICROSCOPE / FLUORESCENCE MICROSCOPE / LIFE SCIENCE
    CorrSight

    CorrSight is the only on purpose built light microscope designed around the requirements in a correlative experiment. It offers true automation in complex workflows thanks to its simple operation and flexibility.

    FEI's CorrSight optimizes the major steps within a correlative experiment. Users can freely configure a fully automated imaging system dedicated to fulfil their experimental requirements. Furthermore CorrSight is run by MAPS: the only correlative software capable of managing the entire workflow from light to electron microscopy, ensuring automated registration of instruments and images together with an astonishing ease-of-use.

  • Desktop SEM / Correlative Microscopy / CLEM
    Delphi

    Delphi is the world's first fully integrated solution that enables fast correlative microscopy with unique overlay precision.

    The system is extremely easy to use for both light- and electron-microscopy users. Even more importantly, Delphi opens the door to these techniques for all laboratories through a cost-efficient package that does not require experienced microscopy skills to image and interpret data.

    In life science imaging, fluorescence microscopy provides precise localization for specific events, while electron microscopy is able to provide detailed structural information with nanoscale resolution and very good depth-of-focus. Combined, the two techniques quickly provide a more complete picture for the user with a technique known as Correlative Light & Electron Microscopy or CLEM.

    This integration enables scientists to do correlative microscopy without the challenges typically associated with CLEM:
    • The Region Of Interest (ROI) does not need to be retrieved, as you are working in the same ROI switching from LM to EM and vice versa.
    • The sample does not need to be transferred from one microscope to the other, saving sample quality as well as time.
    • Correlation accuracy is fully automated and highly precise.

    With the Delphi, CLEM is made accessible for virtually any laboratory thanks to its ease-of-use and affordability. Please also visit www.delphimicroscope.com for more detailed information.

  • DESKTOP SEM / LARGE SAMPLE STAGE
    Phenom XL

    The Phenom XL Scanning Electron Microscope (SEM) pushes the boundaries of compact desktop SEM performance. It features the proven ease-of-use and fast time-to-image of any Phenom system. It is also equipped with a chamber that allows analysis of large samples up to 100 mm x 100 mm. A proprietary venting/loading mechanism ensures the fastest vent/load cycle in the world, providing the highest throughput. A newly developed compact motorized stage enables the user to scan the full sample area, and yet the Phenom XL is a desktop SEM that needs little space and no extra facilities. Ease-of-use is given an extra boost in the Phenom XL with a single-shot optical navigation camera that allows the user to move to any spot on the sample with just a single click – within seconds.

  • DUAL BEAM / SEM / FIB
    Versa 3D Dual Beam

    Building on the history and success of FEI's pioneering DualBeam, low vacuum and ESEM™ expertise, FEI introduces the most versatile DualBeam instrument to date. The Versa 3D offers state-of-the-art imaging and analytical performance to deliver a greater range of 3D data from even your most challenging samples.

    Versa 3D's highly configurable platform allows customers to adapt the system's capabilities to their specific requirements. The combination of high and low vacuum modes gives the flexibility to work with a range of samples including uncoated and non-conductive samples. Optional ESEM mode allows electron beam imaging of naturally hydrated samples and supports in situ analysis and experimentation with additional dynamic temperature stages.

  • MOLECULAR WEIGHT ANALYZER
    BI-MwA Molecular Weight Analyzers

    The BI-MwA Molecular Weight Analyzer is simple to use, but incorporates sophisticated features. Inject your sample into the low-volume, 7-angle flow cell. The sample is illuminated by a temperature stabilized, precision power-controlled diode laser. The ultra-stable, high-sensitivity, low-noise CCD detector automatically collects the scattered light. Then, the software extrapolates the data to zero angle for the absolute molecular weight determination.

  • MOLECULAR WEIGHT ANALYZER / DIFFERENTIAL REFRACTOMETER
    BI-DNDC Laser Light Scattering Instruments

    The BI-DNDC is a deflection type refractometer that may be used in either static or dynamic mode. In static mode, the specific refractive index increment, dn/dc, is determined. This value is required as a parameter in molecular weight measurements using light scattering. In dynamic mode dn/dc is already known, and the instrument is used as a concentration detector for HPLC and GPC applications.

  • PARTICLE SIZE ANALYZER
    MicroBrook 2000L

    The MicroBrook 2000L utilizes a unique single-beam, dual-lens system that receives all the scattered signals emitted from particles in the nanometer to millimeter size range. Employing the highest quality lenses results in high resolution imaging of the diffracted and scattered light with low distortion, ensuring that the instrument will receive all signals – even weak signals at high angles from scattering of the smallest particles.

  • PARTICLE SIZE ANALYZER / MOLECULAR WEIGHT ANALYZER
    BI-200SM

    The Brookhaven Instruments’ BI-200SM system opens the door to the rich fields of exploration of both Static Light Scattering (SLS) and Dynamic Light Scattering (DLS).

    The BI-200SM Research Goniometer System provides access to these studies with an automatic, modular and versatile system. It is a precision
    instrument designed for exacting scattering measurements. Based on a special turntable with precision ball bearings and stepping motor, the BI-200SM’s modern design and quality construction guarantee precise measurements due to the wobblefree movement of the detector. It is field proven in thousands of laboratories. It is ideal for molecular studies and submicron particle sizing.

    Brookhaven Instruments’ scientists have extensive experience in the development of instruments and methods for light scattering and this experience has been incorporated into the BI-200SM to make it the finest instrument available for research applications of light scattering.

  • PARTICLE SIZE ANALYZER / NANO
    NanoDLS

    The NanoDLS is the gateway to absolute nanoparticle sizing including proteins and their aggregates (oligomers), polymers, dendrimers, micelles, and other colloidal materials. Either on-line (ASEC or SEC/GPC), or in batch-mode, it is an excellent tool for determination of hydrodynamic radii from 0.5 to a few microns.

    Based on the principles of dynamic light scattering, the NanoDLS uses an automatic, variable-power laser at 638 nm, maximum 35 mW power, an optical cell design, a singlemode fiber, a self-protecting avalanche photodiode and a 25ns/522 channel digital autocorrelator. Due to the optical cell, the NanoDLS can measure samples from extremely low to high concentrations. Such a design allows for small volumes and a vertical flow pattern, minimizing the effects of bubbles.

    For globular proteins and other rate samples, sizes are often small and concentrations low. Because of its unique optical cell design, the NanoDLS makes obtaining reliable data from such samples easy. In addition aggregate (oligomer) formation is readily probed because light scattering is supremely sensitive to small amounts of larger particles.

  • PARTICLE SIZE ANALYZER / WET & DRY SAMPLES
    MicroBrook 2000LD

    The MicroBrook 2000LD utilizes a unique single-beam, dual-lens system that receives all the scattered signals emitted from particles in the nanometer to millimeter size range. Employing the highest quality lenses results in high resolution imaging of the diffracted and scattered light with low distortion, ensuring that the instrument will receive all signals – even weak signals at high angles from scattering of the smallest particles.

  • PARTICLE SIZE ANALYZER / X-RAY DISC CENTRIFUGE
    BI-XDC

    By providing both centrifugal and gravitational sedimentation in one instrument the BI-XDC brings these well established methods of particle sizing up to date for today's fine particle technology. With an X-ray technology to give error free measurements, fast and accurate size distributions across the ""one-micron"" transition region are easily obtained. Now, with a single instrument you can get true high resolution, accurate, particle size distributions from 10 nanometers right up to 100 microns. Brookhaven's advanced scanning detector technology and wide disc speed range lets you optimize analysis times and broaden the range of samples you can analyze.

    With the Brookhaven Bl-XDC there are no optical corrections and no optical properties to worry about, just a simple mass sensitive response based on X-ray absorption.

  • PARTICLE SIZE ANALYZER / ZETA POTENTIAL ANALYZERS
    NanoBrook Series

    "Characterizing proteins, nanoparticles & polymers confronts the user with a difficult choice of instrumentation. Now Brookhaven Instruments makes that choice easier with its NEW NanoBrook Family. Choose from particle sizing including backscatter for proteins, zeta potential, or combinations including molecular weight determination of small polymers and proteins.

    Particle Sizing and Zeta Potential Combination Instruments
    Select the Omni for sizing proteins, colloids, polymers, and nanoparticles over the entire range and for zeta potential determination of proteins, nanoparticles and colloids in water with salt concentrations up to 2 M ionic strength and in nonpolar or viscous liquids.
    Select the 90Plus PALS for sizing colloids and nanoparticles with diameters greater than 10 nm and for zeta potential determination of proteins, nanoparticles and colloids in water with salt concentrations up to 2 M ionic strength and in nonpolar or viscous liquids.
    Select the 90Plus Zeta for sizing colloids and nanoparticles with diameters greater than 10 nm and for zeta potential determination in water with salt concentrations up to 75 millimolar ionic strength.

    Particle Sizing
    Select the 90Plus for sizing colloids and nanoparticles with diameters greater than 10 nm.
    Select the 173 for sizing of globular proteins and small polymers as low as 1 nm hydrodynamic radius.
    Select the 173Plus for sizing proteins, colloids, polymers and, nanoparticles over the entire range.

    Zeta Potential
    Select the ZetaPlus for zeta potential determination of nanoparticles and colloids in water with salt concentrations less than 75 millimolar ionic strength.
    Select the ZetaPALS for zeta potential determination of proteins, nanoparticles, and colloids in water with salt concentrations up to 2 M ionic strength and in nonpolar or viscous liquids."

  • Preclinical MRI / in vivo Imaging / BioImaging
    VISQUE CleVue

    CleVue™ is a viewer software designed for VISQUE products. The software sets condition for fluorescence and luminescence images and analyses results. The program offers pseudo-colored ideal signal window level and radiance signal value and thus enables researchers to check results on site. As many as ten images can be analyzed at a time, and as many as four images are displayed on a screen for easy comparison among the images under the same condition experiments.

    CleVue™ includes a kinetics analysis program for high-speed imaging with speed of 24fps. The program offers kinetic analysis of time lapse images captured with VISQUE products. With close collaboration with researchers, Vieworks made its best efforts in learning about needs of researchers, and thus reflected them as much as it can to enhance convenience of frequently used functions and offer key analysis functions including automatic calculation of kinetics algorithms. Furthermore, the program is packed with a vast variety of functions relevant for real time imaging to ensure accuracy in kinetic analysis.

  • Preclinical MRI / in vivo Imaging / BioImaging
    VISQUE InVivo Elite

    VISQUE™InVivo Elite is an in vivo imaging device for preclinical phase, with combination of Viework's high performance industrial camera and incomparable technological competence in medical imaging solution.

    Deploying TEC (Thermoelectric Peltier) cooling technology, high performance digital camera cools down camera sensor, as much as 20℃ lower than surrounding temperature. This cooling effect ensures stability in operation despite exposure for long hours, and thus enhances sensitivity of camera. With design to maximize thermo emission of the digital cooling camera and interior of the device, VISQUE™InVivo Elite minimizes noise in images and captures high quality images, maintaining high sensitivity despite long exposure.

    Motor-controlled full HD zoom lens enables easy zooming in and out, opening and closing of aperture, and focusing with software tools. Thus it can offer high resolution images of at least 33㎛. VISQUE InVivo Elite is suitable for luminescent and fluorescent photography from visible rays to near infrared rays. Further, high-speed imaging reaching the maximum of 24 fps and patented mechanical design make real-time fluorescence imaging possible.

    In addition, CleVue™, viewer software for VISQUE™ InVivo Elite, can offers analyzed images and ROI's statistics data for academic papers with analysis tools that has been developed by close and continuous collaboration with researchers.

    VISQUE™InVivo Elite can be used for diverse purposes ranging from research activities on cancer, angiogenesis, liver function, neurology, inflammation disease, to stem cells, and further, analysis on bio functions of cardiovascular and lymphoid organs and pharmacokinetics.

  • Protein Crystallography / Structural Biology / XRD
    XtaLAB MM003

    The XtaLAB MM003 system includes the MicroMax-003 microfocus sealed tube generator coupled to a double-bounce confocal optic and is designed for productive, low-maintenance research in your own lab. The MicroMax-003 is the perfect X-ray source for someone who wants the benefit of a microfocus X-ray source, with low power consumption and long tube life, without the added maintenance that goes with a more powerful rotating anode generator. This system occupies a small footprint, so it can be easily integrated into almost any lab space.

    Optimized for small crystals

    The MicroMax-003 is configured with a specially designed confocal Max-Flux® multilayer optic. This double-bounce optic provides up to 70 times better Cu Kβ suppression compared to single bounce optics, as well as lower divergence and higher intensity. This generator and optic source combination produces a very small beam, less than 100 microns at the crystal, so that more photons are on your small crystals rather than contributing to radiation background. The result is better signal to noise from your diffraction experiments.

    Features:

    • Low maintenance microfocus sealed tube copper X-ray source with confocal double-bounce optics optimized for your detector type (HPAD or IP)
    • Small beam size that is optimized for small crystals
    • System has small footprint for easy integration into any lab space.
    • PILATUS3 R 200K detector with true shutterless data collection capabilities
    • HKL-3000R® for instrument control, data processing and structure solution
    • Ideal system for sample screening prior to synchrotron trips and routine data collection for many samples

  • Protein Crystallography / Structural Biology / XRD
    ACTOR

    Automated crystal transport orientation and retrieval robot

    ACTOR™ is a proven commercial solution for automating routine crystal screening and data collection at both synchrotron beam lines and home laboratories. Compatible with almost any goniometer and detector combination, the ACTOR eliminates much of the physical handling of samples required during crystal screening and data collection.

    Rapid automatic crystal screening

    ACTOR allows you to screen up to 30 samples per hour. Adding automation to your structure solution pipeline also complements the high throughput needed for fragment based screening projects and structural genomics programs. ACTOR enables you to quickly screen many crystals for optimal diffraction qualities and cryo-conditions and includes ranking software to assist you in comparing samples and finding the best crystals for data collection.

    Shorten the crystallization to structure pipeline

    ACTOR allows you to effectively shorten the time gap between crystallization and structure solution. ACTOR was the first commercial automated crystal mounting robot and won the 2002 R&D 100 Award for technical innovation. Today over 60 ACTOR robots are in operation in home labs and at beamlines around the world. ACTOR can increase the number and quality of your diffraction experiments, ensuring your success in increasingly competitive funding and IP environments.

    Features:

    • Completely automated sample mounting, centering and data collection
    • Integrated sample ranking and data collection strategy algorithms.
    • Choice of dewar base plates for use with either ACTOR, ALS, Uni-Puck sample holders. (Tools and magazines for ALS and Uni-Puck must be purchased separately.)
    • Storage capacity up to 240 samples: 3 Dewars with 80 sample capacity per dewar for ALS and UniPuck (Alternatively, 3 dewars with 60 sample capacity per dewar for ACTOR pucks or 3 dewars with 40 sample capacity per dewar for ESRF magazines)

  • Protein Crystallography / Structural Biology / XRD
    HKL-3000R

    Data collection, processing and structure solution software
    Complete unified software solution for protein crystallography

    HKL-3000R represents a new approach in crystallographic data collection software that integrates data collection, data reduction, phasing and model building into a single package. This approach significantly accelerates the process of structure determination and on average minimizes the number of crystals, data sets and time required for structure solution.

    HKL-3000R Is the Most Widely Used Processing Package for Protein Diffraction Data

    At the heart of HKL-3000R lies the most powerful data processing package in the world, HKL-2000. Evidence for this can be seen in the statistics of protein structure submissions to the PDB. No other processing package, commercial or public domain, comes close to matching HKL-2000 in terms of the number of PDB references.

    HKL-3000R is User Friendly

    HKL-3000R is a single user interface that allows for data processing and structure solution. The structure solution pipeline inherent to HKL-3000R seamlessly transfers output from one step to the next. Strategic stopping points are provided in the structure solution software to prevent the pitfalls commonly associated with black-box crystallography.

    In most cases, using the default settings of the program results in a highly complete model of a macromolecule.
    The software can be run in semiautomatic mode, allowing the experimenter to check and change important parameters during diffraction data processing and structure elucidation. During each step, the software provides helpful graphs and tables to analyze results and outcome. These feedback tools are valuable for optimizing parameters for subsequent steps and facilitate the structure solution process. This approach significantly accelerates the process of structure determination and, on average, minimizes the number of crystals, data sets and time required for structure solution.

    Features:

    • HKL-3000R controls the data collection instrument.
    • Data collection strategy calculation for single and multiple axes goniometers.
    • Raw image data reduction and analysis by industry standard HKL-2000
    • Structure solution pipeline uses industry standard software packages (CCP4, SHELX, ARP/wARP, Coot, etc.)
    • Communication with standard databases (PDB, SwissProt)

  • Protein Crystallography / Structural Biology / XRD
    BioSAXS-2000

    Small angle X-ray scattering (SAXS) Kratky camera system
    Protein solution structure determination

    Rigaku's BioSAXS-2000 SAXS camera is designed specifically to meet the needs of the structural biologist. Based on a patented two-dimensional Kratky design, the BioSAXS-2000 takes up much less space than a conventional 3-pinhole camera but offers better flux characteristics. Best of all, the BioSAXS-2000 can be mounted on the open port of a Rigaku rotating anode X-ray generator, taking full advantage of existing infrastructure, or it can be mated to a Rigaku microfocus sealed tube X-ray source. The BioSAXS AUTO configuration incorporates two time-saving features: an Automatic Sample Changer for unattended overnight operation and an Automatic Analysis Pipeline based on the world standard ATSAS package from EMBL Hamburg.

    No need to wait for beamtime at a synchrotron

    The BioSAXS-2000 is equipped with the new OptiSAXS optic, a doubly focusing multilayer optic whose focus is at the detector. The OptiSAXS provides better than two fold improvement in flux compared to its predecessor resulting in higher brilliance at the sample position and data collection times in the range of minutes. Thus, the BioSAXS-2000 brings a beamline experience to home laboratory SAXS experiments.
    Optional accessories

    Automatic Sample Changer (ASC) with support for 8 or 96 samples. See Accessories tab for more details.
    Automatic Analysis Pipeline (AAP) based on ATSAS, the world’s most popular SAXS analysis software developed at EMBL Hamburg. See Accessories tab for more details.

    Features:

    • Automated sample stage with 3 capillary cells and one powder standard position
    • Simultaneous SAXS and WAXS measurements in a single image (qmax = 0.65 Å⁻¹)
    • Easily installed on the open port of an existing generator or can be installed with your choice of X-ray • source: Microfocus sealed tube, MicroMax-007 HF, FR-X
    • Point focusing optics eliminates smearing issues common to traditional Kratky cameras.
    • All system components are motorized for control from control computer
    • Photodiode beamstop for intensity measurements and sample absorption correction
    • Sample temperature control included with system
    • 2D Kratky collimation allows one to achieve low q measurements with no realignment
    • SAXSLab data collection and processing software

  • Protein Crystallography / Structural Biology / XRD
    XtaLAB FR-X

    Single Crystal Diffraction System with Microfocus Rotating Anode Generator
    Structure determination of macromolecules

    The XtaLAB FR-X system includes a VariMax optic coupled with the FR-X rotating anode generator. The FR-X is the most intense home lab X-ray source in the world and enables data collection on the widest range of protein crystal samples. It delivers 2.5 times higher flux compared to the MicroMax-007 HF rotating anode generator but shares the same microfocus 70 μm focal spot size. When coupled with Rigaku’s VariMax optics, the FR-X delivers the highest brilliance for any commercially available rotating anode. As a result, it is possible to collect diffraction data for samples where no diffraction can be seen using a conventional rotating anode or sealed tube source.

    Dual Port System with No Compromise in Beam Intensity

    The FR-X also offers two X-ray ports and optional dual wavelength capabilities. When using both ports, there is no compromise in beam intensity as is observed with metal jet sources, which are known to suffer from lower intensity when used in a dual port configuration.

    Features

    • True microfocus rotating anode X-ray sources with outstanding beam stability
    • Robust direct-drive anode provides extended anode and fi lament lifetimes
    • Increased uptime and ease of use with pre-aligned and pre-aged f laments
    • Your choice of VariMax™ confocal double-bounce optics for better spectral purity and beam size to match your sample types
    • Four-circle goniometer to provide completeness and redundancy for your data sets
    • PILATUS3 R 200K detector with true shutterless data collection capabilities
    • HKL-3000R for instrument control, data processing and structure solution
    • Dual ports allow for dual detectors or dual crystallography and SAXS ports, with NO compromise in beam intensity
    • Dual wavelength option - for in-house phasing or dual macro- and small molecule capabilities

  • Protein Crystallography / Structural Biology / XRD
    Rigaku Reagents

    Rigaku Reagents is a leading provider of protein science solutions. We develop and supply reagent kits, stock solutions, proteins, and accessories for protein researchers. An innovation leader, the team at Rigaku Reagents continues to create award-winning research tools that accelerate discovery and decision-making in protein labs worldwide. Our reagents and stock solutions are available individually, in convenient screens, and as custom products.

  • Protein Crystallography / Structural Biology / XRD
    PILATUS3 R 200K Hybrid Pixel Array Detector

    Hybrid Pixel Array Detector
    Measurement of single crystal X-ray diffraction data

    Rigaku Oxford Diffraction offers the PILATUS3 R 200K as the standard detector for single crystal systems. PILATUS3 R detectors are true photon counting devices that combine the following features to make them the best commercially available detectors for protein crystallography:

    • the highest sensitivity
    • the lowest readout noise
    • the fastest readout time
    • the lowest point spread function
    • fully air-cooled and maintenance free

    Whether you’re collecting data for small or weakly diffracting samples or collecting data for S-SAD phasing, a Rigaku Oxford Diffraction system configured with a PILATUS3 R detector ensures the most accurate data collection for your samples. The PILATUS3 R 200K is also ideal for high throughput screening and ligand binding studies, especially when coupled with an ACTOR automatic sample changer.

    Features:

    • Direct detection
    • Excellent point spread function – top hat
    • Excellent signal-to-noise ratio via single photon counting
    • Adjustable threshold to suppress fluorescence
    • High dynamic range: 1,048,576:1 photons per pixel
    • High counting rates: up to 2x10⁶ photons per second per pixel
    • Short readout time: 7 ms
    • Frame rate up to 20 images per second
    • Electronically gateable
    • Radiation tolerant design
    Other PILATUS3 R format detectors are available: PILATUS3 R 300K, PILATUS3 R 1M

  • Protein Crystallography / Structural Biology / XRD
    XtaLAB MM007-HF

    Single Crystal Diffraction System with Microfocus Rotating Anode Generator

    The XtaLAB MM007-HF system includes a VariMax optic coupled to the MicroMax-007 HF, which provides the best balance between outstanding performance for a wide range of crystal types. As the most popular microfocus rotating anode X-ray source for structural biology, the Rigaku MicroMax-007 HF provides brilliance equaling the very best competitive products with a smaller focal spot and while providing lower cost-of-ownership and higher productivity. High uptimes and "designed-in" maintainability differentiate the MicroMax-007 HF from the competition. The MicroMax-007 HF rotating anode generator offers two ports and can be equipped with detector systems on each. Alternatively, one port can be configured for biological SAXS experiments.

    Features

    • True microfocus rotating anode X-ray sources with outstanding beam stability
    • Robust direct-drive anode provides extended anode and filament lifetimes
    • Increased uptime and ease of use with pre-aligned and pre-aged filaments
    • Your choice of VariMax™ confocal double-bounce optics for better spectral purity and beam size to match your sample types
    • Four-circle goniometer to provide completeness and redundancy for your data sets
    • PILATUS3 R 200K detector with true shutterless data collection capabilities
    • HKL-3000R for instrument control, data processing and structure solution
    • Dual ports allow for dual detectors or dual crystallography and SAXS ports, with NO compromise in beam intensity
    • Dual wavelength option - for in-house phasing or dual macro- and small molecule capabilities

  • Protein Crystallography / Structural Biology / XRD
    PX Scanner

    In situ X-ray crystallography system with imager

    The PX Scanner is a fully integrated system for in situ screening and data collection of crystals in SBS crystallization plates and microfluidic chips. This turnkey system combines sample visualization and in situ X-ray screening to deliver a compact tool to evaluate sample quality without the need to remove crystals from their protected growth environment. The system includes a microfocus sealed tube Cu X-ray generator, crystal imaging system, automated tray stage with 6 degrees of tilt, CCD detector and intuitive CrystalEyes software. With the PX Scanner, one can quickly identify whether a crystal contains salt or protein and evaluate diffraction quality for samples without removal from the crystallization plate.

    CrystalEyes software

    The PX Scanner features the CrystalEyes software that allows users to queue screening of multiple crystals from multiple drops for immediate screening. The software includes automatic data reduction tools and an easy to use GUI for reviewing images and X-ray diffraction results.

    Features

    • Microfocus sealed tube Cu source
    • 135 mm CCD detector
    • Touch-screen control for loading and unloading plates
    • Barcode reader for plate identification
    • Compact footprint

  • Protein Crystallography / Structural Biology / XRD
    PlateMate

    Plate adapter for in-situ X-ray crystallography

    The Rigaku PlateMate is a simple, inexpensive tool for rapid screening of crystals within crystallization plates. The PlateMate supports several different SBS format crystallization plates, though best results are observed using X-ray compatible plates. The PlateMate is quickly installed on Rigaku 4-circle AFC11 partial chi and non-inverted phi goniometers by virtue of the standard IUCr goniometer mount fitting. The plate slides on linear rails to bring the desired well position to the beam, then micrometers allow for fine adjustments to precisely center the desired crystal in the X-ray beam. With the PlateMate, you can detect whether you have protein versus salt crystals within minutes. Moreover, the PlateMate has a compact design so that you can collect X-ray diffraction data sets.

    Features:

    • Allows for rapid screening of crystals within crystallization drops to identify protein crystals versus salt and detergent crystals.
    • Enables screening of crystals which deteriorate as soon as they are taken out of their crystallization environment
    • Supports several SBS format, X-ray compatible crystallization plates.
    • Simple, light and easy-to-use design.
    • Can be set up on a 4-circle goniometer within seconds.
    • The plate position is easily adjusted to screen crystals in any of the crystallization wells.
    • Micrometers allow for fine plate positioning so that even small crystals can be precisely centered into the beam.

  • SEM
    Inspect

    With advanced chamber vacuum technology, the Inspect™ line of scanning electron microscopes (SEM) builds on FEI's world-class electron optics and sample throughput technologies. When inspection, characterization, process control and failure analysis are important, the Inspect S50 and Inspect F50 models' high-resolution imaging is a must. The intuitive user interface and software, with all functions required to record and store an image accessed directly via a tool bar, is well suited for a multi-user environment while full stage access to accommodate a range of specimen holders adds value and flexibility for a range of uses.

    The Inspect line of tools includes two scanning electron microscopes , one SEM with tungsten and another SEM with FEG, for use where high-resolution imaging is routine. These cost-effective, flexible, state-of-the-art scanning electron microscopes are built using FEI's advanced technology, making them valuable for industrial manufacturers and researchers working with material characterization and inspection applications.

  • SEM / ENVIRONMENT SEM
    Quanta

    The FEI Quanta line includes six variable-pressure and environmental scanning electron microscopes (ESEM™). All of which can accommodate multiple sample and imaging requirements for industrial process control labs, materials science labs and life science labs.

    The Quanta line of scanning electron microscopes are versatile, high-performance instruments with three modes (high vacuum, low vacuum and ESEM) to accommodate the widest range of samples of any SEM system. All the Quanta SEM systems can be equipped with analytical systems, such as energy dispersive spectrometer, wavelength dispersive x-ray spectroscopy and electron backscatter diffraction. In addition, the field emission gun (FEG) systems contain a S/TEM detector for bright-field and dark-field sample imaging. Another variable that changes amongst the SEM systems is the size of the motorized stage (50mm, 100mm, and 150mm) and the motorized z-range (25mm, 60mm, and 65mm, respectively). The Quanta 650 and 650 FEG are each designed with a roomy chamber, enabling the analysis and navigation of large specimens.

  • SEM / ULTRA HIGH RESOLUTION (UHR)
    Nova Nano

    The Nova NanoSEM™ scanning electron microscope delivers best in class imaging and analytical performance in a single, easy-to-use instrument. Specifically designed to streamline operations in your laboratory, the Nova NanoSEM enables owners the ability to gain the most comprehensive answers in the least amount of time. This propels productivity, without sacrificing on the quality imaging you demand from your daily work.

    With the Nova NanoSEM 50 series, even more becomes possible. In addition to the powerful combination of advanced optics (including a two-mode final lens), SE/BSE (Secondary Electrons/Backscattered Electrons) in-lens detection and beam deceleration, the Nova NanoSEM 50 series introduces a new suite of latest generation, high sensitivity retractable SE/BSE and STEM detectors, as well as versatile SE/BSE filtering capabilities, to best optimize the information of interest. Intelligent scanning modes are available to minimize imaging artifacts.

  • SPR
    BI-2000 Series

    • Innovative multi-module design
    Provides users with maximum flexibility to choose amongst various analysis modules for diverse applications

    • Compatible with electrochemistry and chemical vapor applications
    Allows for electrochemical SPR studies, chemical vapor detection, gas chemical sensor research, and fundamental solid-gas interface studies (gas module exclusive to BI-2000G model)

    • Two-channel SPR detection module
    For background and reference subtraction in aqueous buffer solution; covers SPR angle range for measuring SPR shift

    • Single and dual channel flow modes
    Allows for more experimental options and enhanced data quality

    • Wide dynamic range and high sensitivity
    High sensitivity (<10-4 degrees) for both large and small molecules (<100 Daltons) enables users to measure binding constants down to a few pM-1

    • Broad response time
    For slow (hours) and fast (< ms) kinetic processes

  • SPR
    BI-3000 Series

    • Semi-automated sample delivery with BI-DirectFlow™ technology
    For ultra-fast kinetics, distinction/extraction of secondary effects, and higher quality results

    • Innovative multi-module design
    Provides users with maximum flexibility to choose amongst various analysis modules for diverse applications

    • Compatible with electrochemistry and chemical vapor applications
    Allows for electrochemical SPR studies, chemical vapor detection, gas chemical sensor research, and fundamental solid-gas interface studies (chemical vapor applications exclusive to BI-3000G model)

    • Two-channel SPR detection module
    Covers wide SPR angle range for measuring SPR shift in liquid and gas phases. Also capable of accurate background and reference subtraction.

    • Single and dual channel flow modes
    Allows for more experimental options and enhanced data quality

    • Wide dynamic range and high sensitivity
    High sensitivity (<10-5 degrees) for both large and small molecules (<100 Daltons) enables users to measure binding constants down to a few pM-1

    • Broad response time
    For slow (hours) and fast (< 0.5 ms) kinetic processes

  • SPR
    BI-4000 Series

    • Temperature controlled two-channel SPR detection module
    Covers wide SPR angle range for measuring SPR shift in liquid phase. Precision background and reference subtraction. Temperature control for thermodynamic studies, 6 to 50 °C.

    • Fully- and Semi-automated options with
    BI-DirectFlow™ Technology
    For ultra-fast kinetics, discernment of secondary effects, and generation of high quality results. Available in fully-automated option with BI Autosampler.

    • Innovative multi-module design
    Provides users with maximum flexibility to choose amongst various analysis modules for diverse applications

    • Compatible with electrochemistry applications
    Allows for electrochemical SPR studies and chemical sensor research.

    • Single and dual channel flow modes
    Allows for more experimental options and enhanced data quality

    • Wide dynamic range and high sensitivity
    High sensitivity (<10-5 degrees) for both large and small molecules (<100 Daltons) enables users to measure binding constants down to a few pM-1

    • Broad response time
    For slow (hours) and fast (< 0.5 ms) kinetic processes

  • TEM / ADVANCE / CRYO-TEM / STRUCTURAL BIOLOGY
    Titan Halo

    Based on the Titan Krios ultimate platform for biological imaging, Titan Halo combines versatility and flexibility with impressive, superior optical quality. Effective biological imaging at the nanoscale requires platforms which are able to take the lowest contrast, sensitive and valuable sample and turn it into revealing, insightful data. Titan Halo excels at delivering application versatility and flexibility without any compromise to optical stability.

  • TEM / ADVANCE / CRYO-TEM / STRUCTURAL BIOLOGY
    Titan Krios

    The Titan Krios is the most powerful and flexible high resolution electron microscope for 2D and 3D characterization of biological samples. The Titan Krios optimal thermal and mechanical stability ensures perfect optical performance. The Titan Krios enables days of unattended operation and the combination with the automated sample loader results in unprecedented sample throughput.

  • TEM / ADVANCE / ENVIRONMENTAL TEM
    Titan ETEM

    Environmental Transmission Electron Microscope for dynamic in situ exploration of functional nanomaterials and devices at the nanometer and atomic scale.

    Built on FEI's world class Titan TEM platform, the Titan ETEM G2 atomic-resolution Scanning/Transmission Electron Microscope (STEM) is an all-in-one solution for time-resolved in situ studies of dynamic behavior of nanomaterials during exposure to gaseous environments. FEI's newest ETEM generation features an innovative differentially-pumped specimen area compatible with standard TEM holders for easy sample handling and full double tilt capability. The software-controlled user interface offers a range of settings to accommodate both handling by novice as well as by advanced operators. A mass spectrometer allows determination of gas composition; a built-in plasma cleaner allows for cleaning after using a gas. Built with the utmost consideration to safe operation, the Titan ETEM G2 complies fully with safety regulations and protocols for gas handling. Titan ETEM G2 is a flexible, easy-to-use solution for imaging of static specimens, observing nanomaterials' dynamic response to the applied stimulus, and observing growth, function, reliability and breakdown of nanodevices.

  • TEM / CRYO-TEM / LIFE SCIENCE / STRUCTURAL BIOLOGY
    Tecnai Artica

    The next generation automated, high resolution imaging TEM platform - Tecnai Arctica provides a platform which combines excellent optical performance and thermal and mechanical stability with high sample throughput. This new platform delivers increased data throughput using a new sample holder that allows for automatic loading of 12 samples. This results in high data throughput coupled with superior optical performance and stability; researchers gain a dramatic reduction in time to data results and achieve lower costs per structure.

  • TEM / MATERIALS / LIFE SCIENCE
    Tecnai

    The FEI Tecnai™ transmission electron microscopes (TEMs) are designed to offer a truly universal imaging and analysis solution for life sciences, materials sciences, nanotechnology, and the semiconductor and data storage industries.

    With nearly twenty models to choose from, the Tecnai G2 Series combines modern technology with the stringent demands of an innovative scientific community.

  • ZETA POTENTIAL ANALYZER / AUTOTITRATOR
    BI-ZTU Autotitrator

    The BI-ZTU, autotitrator option for the NanoBrook zeta potential analyzers is ideal for automatic determination of the isoelectric point, the IEP, of colloidal materials. Four pumps provide unparalled flexibility for optimizing reagent use. The dramatic savings of reduced labor costs will also encourage larger scale studies that will produce more valuable results.

    In addition, the BI-ZTU can be used to evaluate the effect of salt concentration on zeta potential. Also, the surfactant costs can be minimized. Use the BI-ZTU to find the minimum concentration at which the zeta potential does not significantly change.

  • ZETA POTENTIAL ANALYZER / DIELECTRIC CONSTANT METER
    BI-870 Dielectric Constant Meter

    With Brookhaven’s BI-870, measurement of dielectric constants has never been so easy. Simply insert the probe in the liquid to be measured, adjust the two controls on the front panel and read the dielectric constant from the display. The BI-870 can accurately measure in low and high dielectric solvents, including mixtures.

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